MantleBio - Building software to scale data driven discovery in biotech

Revolutionizing Biotech with Data-Driven Discovery: The MantleBio Story

In the heart of San Francisco's bustling tech scene, a dynamic duo is paving the way for a new era in biotech. Meet Emily Damato and Madeline Schade, the visionary co-founders of MantleBio. With their extensive backgrounds in software engineering and life sciences, they are on a mission to revolutionize the biotech landscape by harnessing the power of data-driven discovery.

Unleashing the Untapped Potential of Biotech Data

In an epoch characterized by remarkable advancements in science and technology, the biotech industry stands at the precipice of a data revolution that has the potential to reshape the landscape of scientific discovery. A seismic shift is occurring, with biotech companies now generating staggering volumes of data – terabytes upon terabytes – on a daily basis. This extraordinary influx of data is largely attributed to the pioneering strides made in high-throughput sequencing and screening technologies, which have propelled biotech into an era where data is as abundant as it is valuable.

Yet, amid this data deluge, a stark disparity persists. The vast majority of biotech enterprises, despite their commendable efforts, find themselves grappling with a profound challenge – the inability to fully harness the boundless potential embedded within these torrents of data. It's an impasse that threatens to impede progress and stifle innovation, a challenge that reverberates across labs and boardrooms alike. Enter MantleBio, a beacon of ingenuity that emerges as a transformative force poised to propel the biotech sector into uncharted realms of innovation and discovery.

The Visionary Founders Bridging the Chasm

At the heart of MantleBio's triumphant journey lie the two visionary founders, each a luminous star in their respective domains, whose convergence has birthed a synergy of unparalleled potential. Emily Damato, a dynamic force serving as CEO and Co-Founder of MantleBio, possesses a prodigious journey that meanders through the corridors of esteemed institutions such as GRAIL, Arsenal Bio, The Broad Institute, and Betteromics. A true polymath in the realm of computational biology, Emily's odyssey traverses the spectrum from the hallowed halls of MIT's wet lab to the vanguard of machine learning applications in biotech. This unique trajectory has gifted her with a multifaceted perspective that forms the bedrock of MantleBio's audacious approach to innovation.

Complementing Emily's prowess is Madeline Schade, the formidable CTO and Co-Founder of MantleBio. Armed with a formidable background in software engineering cultivated through tenures at tech titans like Google, as well as roles at Arsenal Bio and GRAIL, Madeline's journey is a testament to her prowess in architecting resilient data pipelines and steering monumental projects towards fruition. A maestro of technology, she has played an instrumental role in crafting MantleBio's intricate technological framework, fortifying it with the resilience and versatility required to revolutionize the biotech data landscape.

Unveiling MantleBio: A Triumph of Innovation

Amid the cacophony of progress, MantleBio emerges as a paragon of innovation, poised to reshape the very foundations of biotech research and discovery. Anchored by a cutting-edge platform that pulsates with ingenuity, MantleBio's significance transcends convention. While seminal tools like Benchling have indelibly transformed the landscape of wet lab research organization, MantleBio unfurls its majestic wings in the realm of the dry lab, endowing scientists and computational biologists with a symphony of capabilities to seamlessly orchestrate and decipher the intricacies of complex biological data.

What propels MantleBio into the pantheon of disruptors is its profound alignment with the burgeoning frontiers of computational science and machine learning. The platform is meticulously crafted to marry the relentless march of technology with the nuances and intricacies of the biotech domain. It stands as a testament to the harmonious union of innovation and necessity, deftly tailored to cater to the unique demands and challenges that biotech researchers grapple with on a daily basis.

In the ever-evolving biotech arena, MantleBio's platform emerges as a beacon of hope, illuminating a path forward that transcends the limitations of conventional wisdom. Its architecture is a testament to the exquisite synergy between the relentless march of technology and the unwavering pursuit of scientific discovery, a union that has the potential to redefine the trajectory of biotech research in ways previously thought unattainable. As MantleBio unfurls its wings, it beckons us to envision a future where data isn't merely an entity to be managed, but an elixir of innovation that propels biotech into realms previously deemed impossible.

The Data Dilemma: A Bottleneck for Biotech

The core challenge MantleBio addresses is the data dilemma that plagues the biotech industry. While the volume of data generated continues to surge, the majority of companies lack the tools and resources to fully exploit this wealth of information. This shortfall has far-reaching implications, affecting everything from replicability of analyses to integration of multiomic datasets. As regulatory demands grow more stringent, the inability to implement robust data practices can jeopardize future experiments and regulatory approvals.

MantleBio's Ingenious Solution

MantleBio's solution is both elegant and effective. At the heart of their platform is the simplification of multiomics with centralized data management. Unlike existing systems that require scientists to design their own schemas, MantleBio collaborates with experts to offer domain-aware data models that are readily available. This innovation significantly reduces the barrier to entry, enabling both no-code users and computational scientists to easily access datasets through the platform's API, CLI, and UI.

Moreover, MantleBio automates the analysis of routine workflows, freeing up researchers' time and streamlining processes. The platform seamlessly integrates with popular systems like Benchling, Notion, and BaseSpace, enabling it to source experimental data directly from the origins. Custom integrations with even the most complex laboratory instruments are made possible through MantleBio's versatile API and data transformation pipelines.

Empowering Computational Biologists

A key differentiator for MantleBio is its emphasis on empowering computational biologists. The platform enables these experts to create bioinformatics pipelines within minutes, eliminating the need for managing cloud infrastructure or writing complex Docker files. This streamlined approach not only enhances productivity but also fosters a culture of innovation, allowing scientists to focus on what truly matters – groundbreaking research.

Paving the Road to Regulatory Success

In an industry characterized by stringent regulations, MantleBio takes proactive steps to ensure its platform aligns with the highest standards. The platform's ability to automatically record version histories for all datasets is a game-changer. Every input, processing step, and output is meticulously documented, creating a comprehensive and auditable graph of all activities within the computational lab. This level of traceability not only expedites future audits but also instills confidence in the reliability of the analyses conducted.

Behind the Scenes: The MantleBio Team

The driving force behind MantleBio's success is its exceptional team. Emily Damato's journey from MIT's wet lab to industry has equipped her with a unique blend of biological insights and software acumen. Her experience spans drug discovery, cell therapy, diagnostics, molecular dynamics simulations, and patient health records, making her a true full-stack computational biologist.

On the other hand, Madeline Schade's journey through Google and prominent biotech companies has shaped her into a seasoned software engineer with a knack for developing large-scale data pipelines. Her work at GRAIL, where she supported a monumental clinical trial, and her involvement in systems handling billions of queries at Google highlight her ability to navigate complex technological landscapes.

Shared Vision: The Birth of MantleBio

The story of MantleBio began when Emily and Madeline crossed paths at GRAIL, a pioneering cancer diagnostic company. Their subsequent journey to Arsenal Bio, a cell therapy firm, shed light on the shared data management challenges faced by biotech companies. It was this realization that fueled the inception of MantleBio, a platform designed to democratize data engineering practices for all players in the life science research realm.

Conclusion: A Glimpse into the Data-Driven Future of Biotech

As MantleBio continues to make waves in the biotech industry, its impact is nothing short of transformative. With Emily Damato and Madeline Schade at the helm, the platform is poised to reshape how biotech companies harness data for discovery. By bridging the gap between computational science, machine learning, and the intricacies of biotech, MantleBio is not merely a startup – it's a beacon guiding the way toward a data-driven future that holds unprecedented promise for scientific innovation.