Mantis Biotechnology is positioning itself as the foundational infrastructure behind a new class of computational systems known as human-in-computer models. Founded in 2025 and based in New York, the startup aims to solve one of the most persistent challenges in life sciences and biomedical research: fragmented, unreliable, and difficult-to-interpret data.

In a software landscape increasingly defined by artificial intelligence, the ability for applications to “talk” to their own data has shifted from novelty to necessity. Inconvo, a startup founded in 2023 and based in Limerick, Ireland, has emerged as a compelling answer to this demand. Built as an open-source platform

In an era where smartphones manage everything from banking to transportation, healthcare has remained stubbornly tied to scheduled appointments and waiting rooms. Prana, a San Francisco–based startup founded in 2025, is attempting to change that paradigm with an ambitious promise: an AI primary care doctor that lives in your

In an era where artificial intelligence is steadily moving beyond text and into the physical world, Overshoot has emerged as a startup determined to redefine how machines see, interpret, and respond to reality in real time. Founded in 2025 and part of the Winter 2026 batch, the San Francisco–based

In the rapidly evolving world of biotechnology, breakthroughs in artificial intelligence have dramatically accelerated the discovery of new drug candidates. Yet, as innovation surges forward on one front, another critical stage of the pipeline struggles to keep up. 10x Science, a San Francisco–based startup founded in 2025 and part

In the rapidly evolving world of artificial intelligence, infrastructure has become the new frontier of innovation. While headlines often focus on breakthrough models and applications, the true bottleneck lies deeper—in the physical and architectural limits of computation itself. Piris Labs, a young startup founded in 2025 and part of

In an era where artificial intelligence is reshaping nearly every business function, accounting has remained surprisingly resistant to change. Small and medium-sized businesses (SMBs), in particular, continue to rely on fragmented tools, manual spreadsheets, and expensive external firms to manage their finances. Balance, a startup founded in 2026 and part

As artificial intelligence rapidly evolves from passive tools into active agents capable of executing tasks, accessing accounts, and making decisions, a new category of risk has emerged alongside unprecedented opportunity. Broad-access AI agents — systems designed to interact with emails, financial tools, developer environments, databases, and enterprise software — promise enormous productivity

In an era when artificial intelligence is rapidly reshaping industries, biotechnology stands at the edge of a profound transformation. CellType, a New York–based startup founded in 2025 and part of Y Combinator’s Winter 2026 batch, is positioning itself at the forefront of that shift. With a team of

In the modern enterprise, finance and accounting departments sit at the center of operational stability. They manage cash flow, ensure compliance, process invoices, and maintain the integrity of financial records. Yet despite the mission-critical nature of their work, many of their daily tasks remain painfully manual — chasing payments, reconciling accounts,

In the rapidly evolving landscape of software development, speed has become both a competitive advantage and a hidden liability. Canary, a Winter 2026 Y Combinator startup based in San Francisco, emerges precisely at this intersection of acceleration and risk. Positioned as the first AI QA engineer that truly understands a

In an era when software systems underpin nearly every industry, production reliability has become a board-level concern. Downtime can cost millions, damage reputation, and erode user trust in minutes. Yet the responsibility for preventing and resolving incidents still falls largely on Site Reliability Engineering (SRE) teams — professionals who must diagnose

PgDog, founded in 2025 and headquartered in San Francisco, delivers a revolutionary solution for PostgreSQL scalability. Built from real-world experience at Instacart during periods of intense growth, PgDog addresses a persistent challenge: how to scale PostgreSQL without extensive application changes. With a unique focus on automatic sharding, query routing, and

In a world where information flows through increasingly complex formats, Parsewise emerges as a vital solution for organizations striving to make swift, accurate decisions. Founded in 2024 and part of the X25 batch, Parsewise offers a groundbreaking platform for extracting canonical data from multifaceted documents. Their approach redefines the standards

VibeGrade emerged in 2023 as a solution to a pervasive and exhausting problem in education: the endless hours teachers spend grading papers. Founded by two young innovators, Daniel and Musa, who themselves witnessed the toll grading took on their high school teachers, VibeGrade set out with a simple mission: to

Authed is a San Francisco-based startup founded in 2025 and accelerated in Y Combinator’s X25 batch. Despite a compact team of two, Authed is solving a major infrastructure challenge: enabling companies to launch production-ready MCP (Multi-Channel Protocol) servers quickly, securely, and reliably. As AI agents rise to prominence as

In the era of AI-driven automation, enterprises are increasingly looking to harness the power of large language models (LLMs) to process, retrieve, and reason over complex multimodal data. Yet, many encounter a major bottleneck: existing Retrieval-Augmented Generation (RAG) frameworks are ill-equipped to handle documents that include both text and visuals

Blaxel is not just another cloud infrastructure provider—it’s a radical rethinking of cloud computing tailored for the era of agentic AI. Founded in 2024 and based in San Francisco, Blaxel was born out of a fundamental realization: traditional cloud services weren’t built for the demands of intelligent

As AI becomes embedded in everything from personal finance assistants to enterprise coding tools, one question looms large: how can we embrace the full power of cloud AI without compromising privacy? Tinfoil, a San Francisco-based startup founded in 2024, offers a bold solution—confidential computing that guarantees provable privacy, no

Opine is not just another social media platform—it’s a radical reimagining of how content is consumed and relationships are built online. Founded in 2024 by Manuj Mishra and Diogo Valdivieso, Opine is at the forefront of a new digital era where AI influencers take center stage. Based in

Uncommon Therapeutics is a trailblazing biotech startup based in San Francisco, founded in 2024 by Noah Auerhahn and Ryan Lim. The company is on a mission to create multi-billion-dollar therapeutics for complex genetic diseases—starting with Rett Syndrome. What sets Uncommon apart is its deeply personal origin, its focus on

Microsoft Word is used by more than 400 million people worldwide, making it one of the most widely adopted tools in modern workplaces. Despite its prevalence, the editing experience within Word has remained mostly unchanged for decades. Professionals still spend countless hours rewriting text, reformatting content, and reviewing drafts. While

In an industry as fast-paced and high-pressure as the restaurant business, time is money, and operational efficiency can make or break a business. Rebolt was founded in 2025 to address a pervasive and costly problem faced by restaurant owners: managerial overhead, inefficiency, and revenue loss caused by operational fragmentation and

Medicare agencies are quietly facing one of the most devastating and under-addressed challenges in the healthcare ecosystem: member churn. Every year, approximately 50% of Medicare Advantage beneficiaries switch or drop their plans, primarily due to poor post-enrollment engagement. Agencies, overwhelmed by compliance, outbound prospecting, and operational inefficiencies, struggle to keep

Founded in 2024 in San Francisco by former Tesla engineers Owen Brake and Ethan Childerhose, Steinmetz is not just another EV startup—it’s a hardware-first platform company on a mission to revolutionize the electric vehicle industry from within. While many companies focus on battery innovation, vehicle design, or software

In an era where AI is transforming nearly every field, from medicine to marketing, agriculture remains one of the most underserved sectors—particularly when it comes to pesticide innovation. Since 2000, pesticide usage has doubled, even as global farmland has shrunk. Despite this intensified chemical warfare against pests, an alarming

In a world where AI agents are increasingly relied upon for critical decision-making, from customer support to legal client evaluation, accuracy is everything. Yet, even the most sophisticated large language models (LLMs) struggle in real-world applications. The best available reasoning models still fall short on non-trivial benchmarks, often achieving less

Lopus AI is a San Francisco-based startup on a mission to transform how businesses find customers. Founded in 2024 by Aamish Ahmad Beg and Danylo Borodchuk, this Y Combinator-backed company (W25 batch) is tackling one of the most frustrating problems in B2B sales: spending hours chasing the wrong leads. Instead

Nuclear Software is redefining the future of hard tech by introducing the first continuous integration (CI) platform purpose-built for engineering simulations. In a world where complex industries like aerospace, automotive, nuclear, and advanced manufacturing rely heavily on simulations to ensure product quality and safety, Nuclear Software eliminates outdated, time-consuming workflows.

In the high-stakes world of healthcare, compliance isn’t optional—it’s a foundational necessity. Hospitals, insurers, and other care providers face an ever-changing maze of federal and state regulations. From HIPAA to CMS guidelines, the patchwork of rules is vast and growing more complex by the day. Even with

Artificial intelligence has become a staple in modern software development. From customer support chatbots to automated analytics assistants, AI agents are increasingly essential tools in digital products. However, integrating these agents into real-world applications remains an engineering nightmare for most developers. Truffle AI addresses this pain point head-on. Despite the

Emojis.com began as a simple side project born out of a single tweet in October 2023. The idea was straightforward yet delightful: create custom emojis using AI. It quickly captured the internet's attention and was soon hailed as the “best app of 2023.” What started as a

E-commerce has come a long way, but it still fails to fully meet shopper expectations. Despite sleek websites and AI-powered recommendations, the core experience of online retail is often clunky, impersonal, and inefficient. Users frequently struggle with poor search functionalities—where only exact keywords produce results—and they face overwhelming

Tergle is a San Francisco-based startup founded in 2024 by childhood friends William and Adam, who met in school in England and have been entrepreneurial collaborators since their early teens. Their previous venture—a nonprofit EdTech platform—scaled to over 500 schools across the UK. Now, they’re turning their

In an era where AI development is moving at breakneck speed, Large Language Models (LLMs) are becoming central to countless applications. But as developers push out features faster than ever, proper observability and evaluation practices are often skipped. Sublingual, a San Francisco-based startup from Y Combinator’s W25 batch, is

In 2024, amidst a growing aviation crisis in the U.S., Enhanced Radar emerged from Y Combinator’s W25 batch with a bold mission: to make American air traffic control (ATC) systems smarter, safer, and more efficient. Founded by Eric Button and Kristian Gaylord, the startup builds AI-powered systems and

Vocality Health is a groundbreaking healthtech startup founded in 2025 by Brogan McPartland and Vivek Jayaram. As part of the W25 Y Combinator batch, the company is taking a revolutionary approach to tackling one of healthcare’s most persistent challenges: language barriers between medical staff and patients. Vocality Health offers

The inception of Mosaic was rooted in a moment of viral potential and personal frustration. The startup's co-founders—former engineers at Tesla—were experimenting with an idea for a fun YouTube video. Their plan was simple yet clever: film traffic in Palo Alto and count how many Cybertrucks

In the complex and fast-paced world of banking, risk decisioning is a critical, yet painfully slow, process. Every time a bank grants a loan, it relies on intricate, manually maintained credit rules that govern who qualifies and under what terms. These credit rules are deeply embedded in legacy systems and

Dollyglot is a next-generation conversational AI startup based in San Francisco, launched in 2024 as part of Y Combinator’s W25 batch. At its core, Dollyglot takes the character-based AI experience popularized by platforms like Character.ai and adds a dramatic visual leap: real-time video avatars. Instead of static profile

SalesPatriot is revolutionizing how American defense firms approach government contracting. By offering an intelligent back-office operating system tailored specifically for the defense sector, this San Francisco-based startup is helping contractors cut through bureaucratic red tape and secure more Pentagon contracts—faster, smarter, and more efficiently. With its unique blend of

In a world where technology is redefining everyday experiences, Weel is setting a new benchmark in road safety and navigation. Founded in 2024 and based in New York, this ambitious startup is on a mission to replace expensive, outdated in-car hardware with a smarter, simpler, and more affordable solution: your

In the fast-paced, high-stakes environment of modern manufacturing, downtime isn’t just an inconvenience — it’s a costly obstacle that chips away at productivity, profit margins, and morale. But what if there was a way to minimize that downtime by empowering frontline workers with instant, AI-powered troubleshooting assistance? That’s

Partcl is a next-generation chip design automation startup founded in 2025 in San Francisco. With a mission to modernize Electronic Design Automation (EDA) using GPU acceleration and AI, the company is setting new benchmarks in speed and efficiency. The startup's signature product, Boson, delivers up to 700x performance

In a time where the speed of software development is constantly accelerating, code review has become a critical but increasingly painful bottleneck. For developers juggling dozens of tasks and for teams managing ever-growing repositories, the process of peer reviewing code has morphed into a slow, error-prone task—especially with the

In an era where artificial intelligence is redefining every industry, few startups have tackled the regulatory and operational complexity of financial services with the depth and precision of Eloquent AI. Founded in 2025 and backed by Y Combinator’s X25 batch, this ambitious five-person team is reshaping how highly regulated

In industries like aerospace, defense, and medical manufacturing, quality control isn't just important—it’s a legal and operational necessity. Every component, no matter how small, must be documented, verified, and traceable. But the traditional process of preparing quality documentation is agonizingly slow, error-prone, and largely manual. For

Avallon AI is a cutting-edge startup founded in 2025 with a mission to revolutionize call operations in the auto and freight industries. As a member of Y Combinator's X25 batch, the company leverages ultra-realistic AI voice agents to automate traditionally labor-intensive and repetitive tasks. By transforming outdated systems

In the ever-evolving landscape of public safety, Code Four emerges as a transformative force aimed at modernizing the workflows of police departments across the United States. Founded in 2025 and based in San Francisco, this innovative startup is leveraging cutting-edge artificial intelligence to streamline one of the most time-consuming and

Founded in 2024, Rimba is a San Francisco-based startup with a mission to transform how sustainability compliance is handled in the bioenergy sector. Developed by co-founders Timothy Daniel and Akshay Sharma, Rimba was created to serve as an AI-powered copilot for compliance teams, helping them gather, analyze, and manage large

In an industry where precision, compliance, and speed determine patient outcomes and market success, SynthioLabs is introducing a transformative ally — AI teammates purpose-built for life sciences. From medical review to commercialization strategies, this startup is redefining how pharma teams operate with intelligent, 24/7 AI-powered support. But what makes SynthioLabs

In a world where AI agents are rapidly evolving to become integral to everyday workflows, Airweave has emerged as a game-changer. Founded in 2025 and part of Y Combinator’s X25 batch, Airweave simplifies the way data is extracted, organized, and made accessible to AI systems. It’s more than

In the ever-evolving world of software development, the line between human and machine-generated code is growing blurrier. With the rise of large language models (LLMs), anyone can now write functional software with little to no formal training. But while the code may compile, a hidden danger lurks beneath the surface:

How Is Auctor Revolutionizing Pre-Sales and Delivery Teams? In the fast-moving world of software implementation and enterprise sales, time is everything. Lengthy discovery processes, misaligned documentation, and disconnected teams often result in delayed deployments and lost revenue. Enter Auctor—an AI-driven platform purpose-built for pre-sales and delivery teams to capture

In the ever-evolving landscape of SaaS startups and product-led growth, data reigns supreme. Yet, even as companies pile up terabytes of user session replays, they struggle to extract actionable insights from them. That’s the friction point Human Behavior was born to address. Founded in 2025 by Amogh Chaturvedi, Skyler

Peppr AI is a groundbreaking platform designed to tackle the growing problem of knowledge management in organizations. It is the world’s first AI-powered knowledge capture system, enabling businesses to turn scattered, disorganized company data into a dynamic, self-improving knowledge hub. With this knowledge hub, companies can maintain startup speed

Dartboard Energy, founded in 2024 and headquartered in San Francisco, is a pioneering start-up that leverages Artificial Intelligence (AI) to address the challenges faced by owners of grid-connected battery projects. The company’s mission is to optimize revenue generation in electricity markets while ensuring regulatory compliance for its users. Dartboard’

In the fast-paced world of manufacturing, efficiency is king. Whether it’s boosting productivity, reducing downtime, or minimizing errors, manufacturers are always looking for ways to improve. Enter Optifye.ai, a promising startup that aims to revolutionize manual assembly lines by leveraging cutting-edge AI and computer vision technologies. Founded in

Maritime Fusion, founded in 2024 and located in San Francisco, is a cutting-edge company focusing on one of the most ambitious technologies in the world: fusion energy. Unlike traditional methods of generating electricity, such as burning fossil fuels or nuclear fission, fusion promises to deliver clean, nearly limitless energy without

SAMMY Labs, founded in 2024 and headquartered in San Francisco, is revolutionizing how businesses handle customer success, onboarding, and support with the help of artificial intelligence (AI). The AI-driven platform, SAMMY, mimics real user behavior, mapping every click within an app to generate tailored content and offer personalized user experiences.

Mercura is a dynamic start-up founded in 2024 in San Francisco, with a mission to revolutionize the way HVAC and building material distributors manage sales quotations. At its core, Mercura’s AI-powered platform automates the traditionally manual and time-consuming process of creating sales quotes, drastically reducing the time spent on

In the world of fleet management, managing expenses can be a cumbersome and time-consuming process. With fuel, maintenance, charging, and other operational costs eating up a significant portion of the budget, companies need efficient and innovative solutions. This is where Rally comes in. Founded in 2025 in Berlin, Germany, Rally

Instinct is a promising startup founded in 2024 with a groundbreaking mission: to revolutionize lunar navigation through the development of GPS satellites for the Moon. Based in San Francisco, Instinct is creating a constellation of satellites designed to provide precise and reliable GPS navigation to companies that will be landing

Excellence Learning is an innovative educational start-up that aims to revolutionize the way math and science are taught to students in grades 4 to 12. Founded in 2025 by a passionate team of former quants, mathematicians, and physics champions, Excellence seeks to complement or even replace traditional private tutoring and

Astro, founded in 2024, is a groundbreaking company positioned as the world’s first AI-driven energy developer. The company has a singular mission: to revolutionize the renewable energy sector by utilizing artificial intelligence to streamline the early-stage development of energy projects. Unlike traditional energy developers, who face immense challenges and

Founded in 2024 in Los Angeles, CA, Splash Inc. is a groundbreaking start-up focused on developing autonomous surface vessels (ASVs) to enhance national security by patrolling critical maritime infrastructure. The company is actively working on a future where traditional naval vessels may no longer be necessary. Splash's goal

Artificial Societies is an innovative startup founded in 2024 with the mission to revolutionize how human societies are simulated using advanced artificial intelligence (AI). The company leverages AI to model large groups of people and simulate their interactions, aiming to offer a deep understanding of human behavior, which is often

Mundo AI is a cutting-edge start-up dedicated to solving one of the most significant challenges in the field of Artificial Intelligence (AI) and Machine Learning (ML): the lack of high-quality multilingual data. Founded in 2024 by a team of talented professionals, the company is actively working on building the world&

In the rapidly evolving world of online education, the ability to transform passive learning into active engagement is more important than ever. Miyagi Labs, an innovative AI-powered platform, is on a mission to address this challenge by converting educational YouTube content into interactive courses. Founded in 2025 by Guang Cui

Paratus Health, founded in 2024, is an innovative start-up located in San Francisco that leverages cutting-edge AI technology to solve long-standing inefficiencies in the healthcare system. The company’s primary product is an AI-powered intake nurse that automates the patient intake process, providing doctors with essential diagnostic insights before a