The American manufacturing sector has long been a symbol of innovation and productivity, from Detroit’s auto lines to aerospace hubs supplying NASA missions. Yet beneath the surface, much of this industry is held together by legacy infrastructure and an aging workforce. A surprising example? Sheet metal. Sheet metal fabrication—

In the modern healthcare landscape, one might expect that something as fundamental as scheduling a doctor’s appointment would be streamlined, seamless, and intelligent. Yet, despite the advancements in AI and digital health, over 42% of patient calls still go unanswered by clinics—due in large part to outdated phone

In today’s digital economy, the rise of solopreneurs—individuals who manage and operate their own businesses—has transformed how work is done across industries. From private chefs and photographers to personal trainers and caterers, these independent professionals are driven by passion. But beneath the surface lies a growing challenge:

In a world racing to integrate Large Language Models (LLMs) into everything—from copilots to search assistants to autonomous agents—one foundational problem remains: pipelines break. And when they do, the debugging process is painfully manual, slow, and often incomplete. That’s where Tropir enters the scene. Founded in 2024

Cascade Space is a next-generation deep space communications company delivering "communications-as-a-service" for lunar and deep space missions. Founded in 2025 by aerospace veterans Jacob Portukalian and Arlen Abraham, the company offers a turnkey solution for space agencies and commercial space ventures that need reliable, scalable, and efficient communication

In a world where software evolves at lightning speed, the hardware industry has remained stuck in a slower lane. Designing machines and robots is still a painstaking process involving endless CAD drawings, manual tweaking, and countless test iterations. Enter MorphoAI, a startup on a mission to bring hardware development into

In today’s rapidly evolving AI landscape, one problem persists: AI agents don’t learn. Despite advancements in natural language processing, multimodal models, and autonomous agents, most tools still rely on rigid, static behavior. AI agents often repeat mistakes, forget lessons from previous tasks, and lack the ability to generalize

In an era of smart everything—phones, homes, cars—email, surprisingly, remains one of the most outdated tools in a professional’s arsenal. Despite decades of innovation elsewhere, most inboxes still resemble the clunky tools of the 2000s: bloated, noisy, and disorganized. Enter Zero, a startup born out of Y

In highly specialized fields like aerospace, fusion energy, or advanced manufacturing, sourcing precision-welded assemblies is a daunting challenge. Projects depend on timely delivery, impeccable quality, and full traceability—yet many contractors still rely on outdated workflows and manual processes. Smaller weld shops, while more cost-effective, often lack the infrastructure to

Kestral is a San Francisco-based startup on a mission to transform how businesses identify, prioritize, and act on high-impact work—particularly across the traditionally disconnected worlds of Sales and R&D. Founded in 2025 by longtime friends and Asana alums Brian Kim and Bernard Xie, Kestral is building an

In an era where AI voice agents are increasingly embedded into customer experiences, one issue remains stubbornly unresolved: reliable quality assurance. Companies deploying AI voice interfaces often face a tedious and manual process of call-testing, repeating the same user prompts dozens of times to ensure consistent responses. The stakes are

Bookkeeping, accounting, and tax filing have long been time-consuming, expensive, and error-prone processes for small and medium-sized businesses (SMBs). Traditional accounting tools like QuickBooks and Xero require manual input and oversight, while even newer human-led services such as Fondo or Finta cannot truly scale. Small businesses are left choosing between

In a world increasingly defined by the speed of information, warfare has remained paradoxically slow. Tactical decisions often take minutes. Lives are lost because a human operator is manually piloting a drone or responding to a visual feed. Notus Autonomous Systems aims to bring military response times down from minutes

BitBoard is a San Francisco-based startup transforming healthcare operations through AI. Founded in 2025 by Connor Jones and Ambar Choudhury, BitBoard provides healthcare providers with AI-powered agents that take on repetitive, manual administrative tasks. These include reviewing patient intake forms, updating charts, and other low-leverage work that consumes significant time

In an age where instant access, 24/7 services, and borderless innovation are becoming the norm, global financial markets remain frustratingly stuck in the past. Enter QFEX, a revolutionary platform designed to modernize the trading experience for everyone, from retail traders to institutional giants. Based in London and founded in

Alkali is a San Francisco-based startup founded in 2025 with an ambitious goal: to transform how chemical projects are designed, scaled, and built. Traditionally, moving from lab-scale chemistry to full-scale production is a high-stakes process, often spanning years and costing hundreds of millions of dollars. Alkali offers a breakthrough: ProcessMate,

Every modern organization runs on tools—CRM dashboards, customer insights trackers, internal workflow pipelines, reporting systems. But for most go-to-market (GTM) teams—sales, customer success, marketing, support—those tools are either rigid off-the-shelf solutions that don't quite fit, or custom builds that sit at the bottom of a

In an era dominated by artificial intelligence, many industries have evolved dramatically — yet scientific research labs still struggle with outdated data practices. Labric, a 2025-founded startup in the Spring Y Combinator batch, is on a mission to modernize the way science works by addressing the most fundamental yet overlooked bottleneck:

In the fast-paced world of software development, speed is everything. Thanks to generative AI tools like GitHub Copilot and ChatGPT, writing code is faster than ever before. But even as coding accelerates, developers are still shackled by a critical bottleneck: slow builds. Build systems—essential for compiling, testing, and deploying

For most modern software teams, end-to-end (E2E) testing is a paradox. It’s critical for delivering reliable web applications, yet implementing and maintaining it often feels like a burden. The core issue? Traditional testing tools like Cypress and Playwright require detailed scripting, brittle selectors, and tedious upkeep. Even no-code testing

Cotool is a San Francisco-based cybersecurity startup founded in 2025 by Max Pollard, Eddie Conk, and Logan Carmody. The company emerged from a shared frustration among seasoned security professionals: despite advances in cybersecurity tooling, security teams continue to drown in repetitive work, fragmented systems, and mountains of documentation. The Cotool

In today’s fragmented healthcare landscape, patients are expected to be their own care coordinators. From tracking medical records across hospitals, to understanding overlapping conditions and managing multiple prescriptions, the burden often falls squarely on the shoulders of individuals—especially those with chronic conditions. Co-founder Viraj Mehta knows this firsthand.

The practice of transactional law is built on precision, structure, and deadlines. But the primary tool most lawyers use—Microsoft Word—was never designed to support the meticulous, collaborative, and error-sensitive workflows required in law firms. Drafting a high-stakes contract in Word today is, as the Vesence team describes it,

In the world of logistics, time-critical shipping is a space where precision, reliability, and speed can mean the difference between success and catastrophe. This is especially true in industries like healthcare, where a delay in delivering life-saving treatments, or in manufacturing, where downtime due to a missing part can cost

The world of financial auditing is complex, precise, and highly time-sensitive. Yet, it remains shackled by inefficiencies that waste both time and talent. Auditors today are spending nearly half of their working hours on menial, low-value tasks: chasing down documents, manually checking figures, and combing through PDFs. These activities, while

In the age of large language models (LLMs) like ChatGPT, Gemini, and Claude, the way people discover brands has fundamentally changed. Traditional SEO tools and strategies—designed for search engines like Google—are rapidly losing relevance as users turn to AI-powered assistants for answers, recommendations, and decisions. For most companies,

In the dynamic world of blue-collar services—janitorial, landscaping, HVAC, pest control, and pressure washing—growth often feels out of reach. Many business owners are hands-on operators, frequently in the field themselves, managing client relationships and delivering services with little time or energy left for sales and marketing. Despite strong

Modern healthcare organizations are rich in data but poor in insight. Hospitals, health systems, and health plans generate immense volumes of clinical, operational, and financial data—yet this data remains scattered across disconnected systems. From Electronic Health Records (EHRs) to finance software, staffing platforms, and procurement tools, the challenge isn&

In the fast-paced world of software development, security has become an ever-expanding pain point. While companies scale up development thanks to AI-assisted coding, traditional security tools remain slow, fragmented, and often ineffective. Vulnerability scanners frequently produce overwhelming volumes of false positives—30 to 50% on average—wasting valuable engineering time.

In 2025, ValueMate launched with a bold mission: to automate the real estate appraisal process using cutting-edge AI and LiDAR technology. The startup emerged at a critical moment for the appraisal industry, just as new federal regulations began reshaping how property valuations must be conducted. With the September enforcement of

Propolis is an AI-powered quality assurance (QA) platform that automates testing by simulating real users through swarms of autonomous browser agents. Founded in 2025 and based in New York, the startup emerged from the Spring 2025 Y Combinator batch with a radical proposition: hands-off QA. By replacing manual testing and

In the fast-paced world of mobile development, maintaining product quality while accelerating release cycles has become a monumental challenge. Bugs that slip through testing phases cause real damage—crashes that tank app store ratings, broken purchase flows that drive away users, and regressions that sneak past supposedly “green” CI pipelines.

The logistics and trucking industry is the invisible backbone of the global economy, responsible for transporting nearly 70% of all goods across the United States. Despite its centrality, much of the industry’s operational infrastructure remains stuck in the past. In countless dispatch offices across the country, trucking companies still

Independent grocery stores operate on razor-thin margins, making every aspect of daily operations critical to their survival. Shrinkage—the loss of inventory due to theft, damage, or administrative error—accounts for approximately 3% of total sales, directly eroding profitability. Meanwhile, out-of-stock situations wipe out another 4% of potential revenue, as

StarSling is a next-generation developer portal designed to eliminate the invisible tax developers pay when dealing with non-coding tasks. Founded in 2025 and part of Y Combinator’s Spring 2025 batch, StarSling introduces an agentic homepage that automates time-consuming tasks like deployments, debugging, incident resolution, and performance optimization. This isn&

In the intricate and high-stakes world of engineering, the journey from concept to reality often begins not with creativity but with constraint. Whether developing fusion reactors, fine-tuning semiconductor fabrication, or evaluating materials for aerospace systems, engineers face an all-too-familiar bottleneck: simulations. These simulations—used to model the behavior of physical

In today's increasingly interconnected digital landscape, the smallest coding oversight can turn into a catastrophic security breach. With the rise of “vibe coding” and the democratization of development tools, more developers than ever are pushing code into public and private repositories—often unknowingly exposing sensitive secrets in the

For the first time in over two decades, Google's dominance in the search engine market has shown signs of decline. The rise of AI search platforms like ChatGPT, Perplexity, and others is reshaping how people find answers, make decisions, and discover new brands. Traditional SEO — built around keyword

In the world of enterprise sales, precision is everything — yet most sales teams are armed with generic tools that fail to deliver actionable insight. Enter Sixtyfour, a San Francisco-based startup founded in 2025. Sixtyfour is building the Bloomberg Terminal for Sales, empowering hypergrowth companies to deploy custom research agents that

In the high-stakes world of hedge funds and investment firms, accuracy, speed, and efficiency are non-negotiable. Yet one of the most critical foundational processes — data cleaning — remains shockingly manual. Financial analysts and data engineers often find themselves combing through spreadsheets, reviewing PDFs, translating foreign documents, or even reviewing emailed data

For decades, software integration has been a barrier to automation, innovation, and operational efficiency—especially in industries like logistics, healthcare, and finance. Despite advancements in API technology, many legacy portals remain “closed off,” requiring manual data entry and retrieval. Workers in these sectors often interface with dozens—or even hundreds—

In the heart of the global manufacturing industry lies a mounting crisis — a severe shortage of labor and an overwhelming demand for adaptable, efficient automation. Over 70% of factories worldwide report labor shortages. At the same time, current industrial robots struggle to keep pace with constantly shifting production requirements. Traditional

In today’s world, software infrastructure underpins everything from global financial systems to critical healthcare applications. As this infrastructure becomes increasingly reliant on AI-generated code, it simultaneously becomes more vulnerable. Bugs, misconfigurations, and overlooked security gaps can become gateways for attackers — especially in mission-critical environments like cryptography or GPU-accelerated computation.

In the modern age of artificial intelligence, every innovation comes with an equivalent rise in potential vulnerabilities. While AI systems are transforming industries—from finance and healthcare to logistics and legal services—they are also opening doors to new categories of cyberattacks that traditional security tools were never built to

Wholesale distribution is a $9 trillion industry made up of over 410,000 businesses and 6 million employees. It’s a massive and essential backbone of the global supply chain—but it’s also buckling under a growing strain. Sales teams in distribution companies are overloaded. With nearly a third

For decades, the mortgage lending industry has remained shackled to outdated processes and inefficient systems. While digitization has touched many industries, mortgages continue to rely on labor-intensive workflows. Nearly 80% of employees at traditional lending institutions still spend their time on manual tasks—filling out forms, reviewing documents, and transferring

HABIT is a robotics startup founded in 2025 that is taking a bold and practical approach to automating labor-intensive neighborhood services. Based in El Segundo, California, and supported by Y Combinator’s Spring 2025 batch with Diana Hu as its primary partner, HABIT is rethinking how physical tasks like car

In most modern companies, internal tooling is a silent crisis. Marketing teams rely on engineers to generate campaign reports. Operations staff wait weeks for custom dashboards. Finance departments struggle to extract data from disconnected systems. The result? Workflows stitched together with spreadsheets, rigid SaaS tools, and brittle no-code solutions that

The LLM Data Company (TLDC), founded in 2025 and based in San Francisco, is on a mission to bring structure, clarity, and control to one of the most complex challenges in machine learning: evaluating language models and defining reward systems for reinforcement learning (RL). The team—Gavin Bains, Joseph Besgen,

The origin of Ticket Wallet is rooted in personal frustration. Founders Truman Gelnovatch and Ryan Clare—college friends who met on the Princeton Men’s Soccer team—turned a shared pain point into a powerful product. Truman had been manually flipping tickets for five years, juggling spreadsheets and constantly adjusting

In software development, documentation is a critical yet chronically neglected part of the workflow. Despite its undeniable value—especially for onboarding, knowledge sharing, and reducing support requests—few developers enjoy writing it, and even fewer teams maintain it effectively. As a result, documentation often falls out of sync with code,

Every salesperson knows the scenario: you're mid-call with a prospect, and suddenly you're hit with a tough question. Do you lower the price? Can your product handle an obscure technical request? Should you push for the close or nurture longer? In these high-pressure moments, it’s

Bramante Biologics is on a mission to bring pharmaceutical manufacturing back to the United States—and to do it faster, smarter, and more securely than ever before. Founded in 2024 and based in Cambridge, Massachusetts, this cutting-edge startup is part of the Spring 2025 Y Combinator batch and is led

In an AI-first world where Large Language Models (LLMs) and agent-based systems are rewriting how products are built, one constant remains: great models require great data. Yet, despite all the technological advancement in generative AI, data annotation — a critical pillar of model improvement — remains stuck in the past. Enter Besimple

In today’s hyper-competitive digital landscape, companies rise and fall based on how well they understand their users. The painful reality is that most don’t. According to industry statistics and product failure postmortems, 90% of product flops are tied to flawed assumptions about user needs. The intent might be

In an enterprise world where compliance, accuracy, and trust reign supreme, Clarm stands out as an AI innovation built from the ground up for high-stakes environments. Founded in 2025 and based in San Francisco, Clarm is an “Enterprise Agent Builder” designed to eliminate hallucinations—the fabricated or incorrect responses often

In today’s tech-driven world, regulatory compliance is no longer optional—it’s a requirement. Yet for most startups and scaling companies, compliance processes like SOC 2, HIPAA, or ISO27001 are a painful distraction. Founders and engineers often find themselves buried under checklists, evidence collection, control mapping, and risk assessments—

In an era where artificial intelligence applications demand increasingly complex data architectures, HelixDB emerges as a timely and essential innovation. Founded in 2025 and based in San Francisco, HelixDB is a graph-vector database purpose-built to support retrieval-augmented generation (RAG) and AI applications. Developed by founders Xavier Cochran and George Curtis,

Chiron is an innovative iPad application poised to revolutionize the way students learn mathematics, particularly algebra - by offering real-time feedback on handwritten math work. Described as “Grammarly for math,” Chiron interprets math as it is written, analyzing every stroke and providing accurate, immediate feedback to students. This approach bypasses

The creator economy has evolved from a niche trend into a powerhouse of economic activity. With over $250 billion circulating through platforms like YouTube, Twitch, TikTok, Patreon, Substack, and Instagram, millions of individuals have turned content creation into legitimate, lucrative careers. These creators are entrepreneurs in every sense of the

The rent-to-own furniture industry caters to customers who often can’t access traditional financing due to poor or no credit history. While this inclusivity is a core strength, it also introduces operational headaches—chief among them, consistent late payments. These stores often write their own rental contracts, bypassing external financing

In the modern age of business hyper-growth and information overload, scaling a company isn’t just about hiring faster — it’s about staying organized, agile, and aligned. As teams grow, leaders often find themselves buried under a mountain of tools, status update meetings, and endless Slack threads. According to the

Mobile app development has long been restricted to those with deep technical knowledge, expensive infrastructure, and access to specialized tools. Building even the simplest mobile app typically involves learning complex programming languages like Swift or Kotlin, managing backend infrastructure, navigating developer accounts, and enduring the often unpredictable gauntlet of App

VoiceOS is a San Francisco-based startup redefining the hiring process for front-line roles in large organizations. With its voice-powered AI agents, the company automates interviews to screen every applicant the moment they apply, offering an intelligent, scalable alternative to traditional recruiting workflows. Founded in 2023 and part of the Spring

Sygaldry Technologies is a cutting-edge startup developing quantum-accelerated AI servers designed to radically improve the performance, efficiency, and accessibility of artificial intelligence systems. Founded in 2024 and part of Y Combinator’s Spring 2025 batch, the company is led by quantum hardware veteran Chad Rigetti and tech strategist Idalia Friedson.

In 2025, a team of brilliant physicists from Stanford and Harvard launched Photonium, a Palo Alto-based startup with a bold mission: to transform the world of optical design through artificial intelligence. While countless industries rely on advanced optics—from quantum computing to biomedical imaging—most optical systems are still designed

In the ever-evolving world of software development, one challenge remains stubbornly persistent: documentation. Developers love writing code, but rarely do they enjoy documenting it. Incomplete, outdated, or missing internal documentation can lead to onboarding delays, misunderstandings, and ultimately, inefficient teams. Enter Nimbic AI, a startup founded in 2025 by Ishan

Founded in 2025 and based in New York, Trapeze is a healthcare technology startup revolutionizing the way patients and providers connect. Positioned at the intersection of artificial intelligence and medical operations, Trapeze is not just building another scheduling tool—it’s crafting an AI-native version of Zocdoc for the modern

As artificial intelligence systems—particularly conversational agents—rapidly proliferate across customer service, healthcare, finance, and enterprise tools, a serious blind spot remains: how do you truly know your AI is ready for the real world? Despite advances in large language models (LLMs), most teams still test their AI agents manually,